https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45560 Wed 28 Feb 2024 15:21:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40457 Wed 27 Jul 2022 11:14:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45105 Wed 26 Oct 2022 13:21:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42510 0.05). High ratings of participant satisfaction (4.73), enjoyment (4.54) and perceived value (4.54) were observed. Conclusion: This study demonstrates the efficacy and feasibility of delivering a novel HIIT program in the university setting.]]> Wed 24 Aug 2022 09:46:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51394 Wed 24 Apr 2024 12:04:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41428 Wed 22 Mar 2023 10:36:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47103 Wed 14 Dec 2022 09:51:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45779 Wed 13 Mar 2024 08:57:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54483 Wed 13 Mar 2024 07:46:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22166 Wed 11 Apr 2018 11:03:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39907 P < .001) and was greatest for colonoscopy procedures. Restrictions in case volume and trainee activity were common barriers. A total of 71.9% were concerned that the COVID-19 pandemic could prolonged training. Anxiety was reported in 52.4% of respondents and burnout in 18.8%. Anxiety was independently associated with female gender (odds ratio [OR], 2.15; P < .001), adequacy of personal protective equipment (OR, 1.75; P = .005), lack of institutional support for emotional health (OR, 1.67; P = .008), and concerns regarding prolongation of training (OR, 1.60; P = .013). Modifying existing national guidelines to support adequate endoscopy training during the pandemic was supported by 68.9%. Conclusions: The COVID-19 pandemic has led to restrictions in endoscopic volumes and endoscopy training, with high rates of anxiety and burnout among endoscopy trainees worldwide. Targeted measures by training programs to address these key issues are warranted to improve trainee well-being and support trainee education.]]> Wed 07 Feb 2024 15:45:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29046 4000 Kcal/day for those weight stable at the highest levels of morbid obesity (up to BMI 97 kgm⁻²). Fat intakes are also high, around 40% of energy intake and up to 57% for some individuals. Suboptimal intakes of iron and calcium are reported. Conclusion: This review draws attention to a limited evidence base, offers preliminary insight suggesting individuals with morbid obesity are prone to consuming poor quality diets similar to those reported for obese populations, and highlights challenges for future research.]]> Wed 06 Apr 2022 14:03:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42651 Wed 01 Mar 2023 15:00:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39563 Tue 26 Jul 2022 15:12:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42433 Tue 23 Aug 2022 09:58:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48573 8 h/d sitting time, smoking, and frequent consumption of fast food were positively associated with frequent insufficient sleep (P < .05). Higher levels of physical activity and being aged 51 years or older were negatively associated with frequent insufficient sleep (P < .05). Conclusions: The sociodemographic and behavioral characteristics associated with frequent perceived insufficient sleep can be used to guide the development of future interventions to reduce sleep insufficiency.]]> Tue 21 Mar 2023 16:28:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42002 Tue 16 Aug 2022 16:44:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41979 Tue 16 Aug 2022 15:48:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41965 Tue 16 Aug 2022 14:45:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39120 n = 4) while no reason was given in four studies. Seven studies reported that through screening, pharmacists could identify adults with undiagnosed depression. Pharmacists referred adults screening positive for assessment in seven studies and followed up participants in two studies. No study assessed the impact of screening on depressive symptoms or the cost-effectiveness of pharmacists screening for depression. Conclusion: Community pharmacists are able to use depression screening tools to identify undiagnosed adults having symptoms of depression. However, there is little evidence around the impact of this screening on clinical and economic outcomes. Larger, well-designed studies that use a highly accurate, easily administered screening tool and include patient referral and follow-up and pharmacist training are warranted to provide evidence on the impact of community pharmacists screening adults for depression.]]> Tue 10 May 2022 17:14:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41379 Tue 04 Apr 2023 19:08:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41753 Thu 30 Mar 2023 16:09:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39914 Thu 30 Jun 2022 11:34:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40967 Thu 21 Jul 2022 08:38:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39649 Thu 16 Jun 2022 15:16:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43251 Thu 15 Sep 2022 10:24:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51489 Thu 07 Sep 2023 10:52:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40305 Thu 07 Jul 2022 16:14:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36743 Thu 02 Jul 2020 16:38:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18893 Sun 26 Jul 2015 16:15:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41248 Sat 30 Jul 2022 12:40:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13977 Sat 24 Mar 2018 08:24:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18980 i = 10 µM at 100 nM Ca²⁺) that was similar to RyR2 from rat and sheep obtained under the same experimental conditions. However, in the presence of 0.1 mM Ca²⁺, RyR2s from human were 3.5-fold less sensitive to cytoplasmic Mg²⁺ inhibition than those from sheep and rat. The Kₐ values for luminal Ca²⁺ activation were similar in the three species (35 µM for human, 12 µM for sheep, and 10 µM for rat). From the relationship between open probability and luminal [Ca²⁺], the peak open probability for the human RyR2 was approximately the same as that for sheep, and both were ~10-fold greater than that for rat RyR2. Human RyR2 also showed the same sensitivity to luminal Mg²⁺ as that from sheep, whereas rat RyR2 was 10-fold more sensitive. In all species, modulation of RyR2 gating by luminal Ca²⁺ and Mg²⁺ only occurred when cytoplasmic [Ca²⁺] was <3 µM. The activation response of RyR2 to luminal and cytoplasmic Ca²⁺ was strongly dependent on the Mg²⁺ concentration. Addition of physiological levels (1 mM) of Mg²⁺ raised the Kₐ for cytoplasmic Ca²⁺ to 30 µM (human and sheep) or 90 µM (rat) and raised the Kₐ for luminal Ca²⁺ to ~1 mM in all species. This is the first report of the regulation by Ca²⁺ and Mg²⁺ of native RyR2 receptor activity from healthy human hearts.]]> Sat 24 Mar 2018 07:58:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:108 Sat 24 Mar 2018 07:42:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25390 30 min were associated with lower dietary quality, higher alcohol consumption, higher sitting time, more frequent insufficient sleep and poorer overall pattern of lifestyle behaviors. Greater variability in wake times, usual bed times and usual wake times were inconsistently associated with lifestyle behaviours. Conclusions: Greater bed-time variability is associated with a less healthy pattern of lifestyle behaviors. Greater consistency in sleep timing may contribute to, or be reflective of, a healthier lifestyle.]]> Sat 24 Mar 2018 07:39:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29662 n = 18 886; ELSA, n = 9181; HRS, n = 19 303; and SHARE, n = 29 917. The microdata, along with further details about the harmonization process and all metadata, are available through the World Health Organization (WHO) data archive at [http://apps.who.int/healthinfo/systems/surveydata/index.php/catalog]. Further information and enquiries can be made to [sagesurvey@who.int] or the corresponding author. The data resource will continue to be updated with data across additional waves of these surveys and new waves.]]> Sat 24 Mar 2018 07:32:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30170 Sat 24 Mar 2018 07:26:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52861 100, one contributing to meta‐analysis), mean age range 27 to 54 years). We identified one ongoing study and three studies awaiting classification. One study was synthesised narratively, and another involved participants specifically with asthma‐COPD overlap. Most programmes were outpatient‐based, lasting from three to four weeks (inpatient) or eight to 12 weeks (outpatient). Education or self‐management components included breathing retraining and relaxation, nutritional advice and psychological counselling. One programme was specifically tailored for people with severe asthma. Pulmonary rehabilitation compared to usual care may increase maximal oxygen uptake (VO2 max) after programme completion, but the evidence is very uncertain for data derived using mL/kg/min (MD between groups of 3.63 mL/kg/min, 95% confidence interval (CI) 1.48 to 5.77; 3 studies; n = 129) and uncertain for data derived from % predicted VO2 max (MD 14.88%, 95% CI 9.66 to 20.1%; 2 studies; n = 60). The evidence is very uncertain about the effects of pulmonary rehabilitation compared to usual care on incremental shuttle walk test distance (MD between groups 74.0 metres, 95% CI 26.4 to 121.4; 1 study; n = 30). Pulmonary rehabilitation may have little to no effect on VO2 max at longer‐term follow up (9 to 12 months), but the evidence is very uncertain (MD −0.69 mL/kg/min, 95% CI −4.79 to 3.42; I2 = 49%; 3 studies; n = 66). Pulmonary rehabilitation likely improves functional exercise capacity as measured by 6‐minute walk distance, with MD between groups after programme completion of 79.8 metres (95% CI 66.5 to 93.1; 5 studies; n = 529; moderate certainty evidence). This magnitude of mean change exceeds the minimally clinically important difference (MCID) threshold for people with chronic respiratory disease. The evidence is very uncertain about the longer‐term effects one year after pulmonary rehabilitation for this outcome (MD 52.29 metres, 95% CI 0.7 to 103.88; 2 studies; n = 42). Pulmonary rehabilitation may result in a small improvement in asthma control compared to usual care as measured by Asthma Control Questionnaire (ACQ), with an MD between groups of −0.46 (95% CI −0.76 to −0.17; 2 studies; n = 93; low certainty evidence); however, data derived from the Asthma Control Test were very uncertain (MD between groups 3.34, 95% CI −2.32 to 9.01; 2 studies; n = 442). The ACQ finding approximates the MCID of 0.5 points. Pulmonary rehabilitation results in little to no difference in asthma control as measured by ACQ at nine to 12 months follow‐up (MD 0.09, 95% CI −0.35 to 0.53; 2 studies; n = 48; low certainty evidence). Pulmonary rehabilitation likely results in a large improvement in quality of life as assessed by the St George's Respiratory Questionnaire (SGRQ) total score (MD −18.51, 95% CI −20.77 to −16.25; 2 studies; n = 440; moderate certainty evidence), with this magnitude of change exceeding the MCID. However, pulmonary rehabilitation may have little to no effect on Asthma Quality of Life Questionnaire (AQLQ) total scores, with the evidence being very uncertain (MD 0.87, 95% CI −0.13 to 1.86; 2 studies; n = 442). Longer‐term follow‐up data suggested improvements in quality of life may occur as measured by SGRQ (MD −13.4, 95% CI −15.93 to −10.88; 2 studies; n = 430) but not AQLQ (MD 0.58, 95% CI −0.23 to 1.38; 2 studies; n = 435); however, the evidence is very uncertain. One study reported no difference between groups in the proportion of participants who experienced an asthma exacerbation during the intervention period. Data from one study suggest adverse events attributable to the intervention are rare. Overall risk of bias was most commonly impacted by performance bias attributed to a lack of participant blinding to knowledge of the intervention. This is inherently challenging to overcome in rehabilitation studies. Authors' conclusions: Moderate certainty evidence shows that pulmonary rehabilitation is probably associated with clinically meaningful improvements in functional exercise capacity and quality of life upon programme completion in adults with asthma. The certainty of evidence relating to maximal exercise capacity was very low to low. Pulmonary rehabilitation appears to confer minimal effect on asthma control, although the certainty of evidence is very low to low. Unclear reporting of study methods and small sample sizes limits our certainty in the overall body of evidence, whilst heterogenous study designs and interventions likely contribute to inconsistent findings across clinical outcomes and studies. There remains considerable scope for future research.]]> Mon 30 Oct 2023 10:01:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53439 Mon 27 Nov 2023 11:47:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54966 Mon 25 Mar 2024 12:11:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49541 Mon 22 May 2023 08:45:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41581 Mon 22 Apr 2024 14:20:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40749 0.05) and type of services (β = 0.025; p>0.05) had a positive moderating effect on the relationship between health system structure and outcome but were not significant. Conclusion: Improvements to mental health system structure and the process could promote the quality of services as experienced by consumers. Government stakeholders are encouraged to accordingly strengthen health systems with the aim of improving the mental health outcomes for consumers.]]> Mon 18 Jul 2022 13:33:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53031 Mon 13 Nov 2023 08:45:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45642 Mon 06 Feb 2023 15:23:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51400 Mon 04 Sep 2023 14:51:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40013 Mon 04 Jul 2022 08:54:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47198 Fri 30 Jun 2023 10:59:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55390 Fri 24 May 2024 10:33:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39719 Fri 17 Jun 2022 17:31:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39973 2) at baseline. Subjects/methods: A total of 4083 young women (27–31 years) in the healthy weight range (≥18.5 BMI <25 kg/m²) enroled in the Australian Longitudinal study on Women’s Health (ALSWH) were analysed. Diet quality was measured by the Australian Recommended Food Score (ARFS) and the Fruit and Vegetable Index (FAVI) using dietary data derived from a validated food frequency questionnaire. Weight change was calculated as the difference between baseline and 6-year follow-up weight (kg). Multiple linear regression models were used to analyse the association between baseline ARFS and FAVI and 6-year weight change. Results: At baseline, mean diet quality was low for both indices [ARFS (maximum 72) = 29.9 and FAVI (maximum 333) = 94.2] and women gained 3.7 kg of weight during 6 years of follow-up. Regression modelling revealed that every one point increase over 6 years in either the ARFS or FAVI score was associated with statistically significantly less weight gain over 6 years, although the amount was small (33 and 12 g, respectively). Conclusions: Higher diet quality predicts lower prospective weight gain in young women however, further research is needed over a longer follow-up period and in diverse population groups.]]> Fri 15 Jul 2022 10:18:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39992 p < 0.001). Many survivors and parents have unmet needs for genetics-related services and information. Greater access to services and information might allow survivors at high risk for late effects to detect and prevent side effects early and improve medical outcomes. Addressing families’ needs and preferences during survivorship may increase satisfaction with survivorship care.]]> Fri 15 Jul 2022 10:13:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41815 Fri 12 Aug 2022 12:45:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41715 18 years) in nonclinical and clinical settings. Screening and data extraction were undertaken by independent reviewers, with discrepancies resolved by consensus. Narrative synthesis described participants, mEMA target, protocol, and compliance. Random effects meta-analysis explored factors associated with cohort compliance (monitoring duration, daily prompt frequency or schedule, device type, training, incentives, and burden score). Random effects analysis of variance (P≤.05) assessed differences between nonclinical and clinical data sets. Results: Of the 168 eligible studies, 97/105 (57.7%) reported compliance in unique data sets (nonclinical=64/105 [61%], clinical=41/105 [39%]). The most common self-reported mEMA target was affect (primary target: 31/105, 29.5% data sets; secondary target: 50/105, 47.6% data sets). The median duration of the mEMA protocol was 7 days (nonclinical=7, clinical=12). Most protocols used a single time-based (random or interval) prompt type (69/105, 65.7%); median prompt frequency was 5 per day. The median number of items per prompt was similar for nonclinical (8) and clinical data sets (10). More than half of the data sets reported mEMA training (84/105, 80%) and provision of participant incentives (66/105, 62.9%). Less than half of the data sets reported number of prompts delivered (22/105, 21%), answered (43/105, 41%), criterion for valid mEMA data (37/105, 35.2%), or response latency (38/105, 36.2%). Meta-analysis (nonclinical=41, clinical=27) estimated an overall compliance of 81.9% (95% CI 79.1-84.4), with no significant difference between nonclinical and clinical data sets or estimates before or after data exclusions. Compliance was associated with prompts per day and items per prompt for nonclinical data sets. Although widespread heterogeneity existed across analysis (I2>90%), no compelling relationship was identified between key features of mEMA protocols representing burden and mEMA compliance. Conclusions: In this 10-year sample of studies using the mEMA of self-reported health-related behaviors and psychological constructs in adult nonclinical and clinical populations, mEMA was applied across contexts and health conditions and to collect a range of health-related data. There was inconsistent reporting of compliance and key features within protocols, which limited the ability to confidently identify components of mEMA schedules likely to have a specific impact on compliance.]]> Fri 12 Aug 2022 08:54:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46943 METTL15). The variant was nominally associated with only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than 10 single nucleotide polymorphisms (SNPs) (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.]]> Fri 09 Dec 2022 14:01:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51515 Fri 08 Sep 2023 12:04:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41596 Fri 05 Aug 2022 14:58:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37431 Fri 03 Dec 2021 10:32:45 AEDT ]]>